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The patients involved in the study had stage T3-T4 prostate cancer, meaning the disease was locally advanced but had not yet spread to the lymph nodes or other parts of the body.

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Locally advanced prostate cancer is not treated with surgery because the cancer has already left the prostate. Thus, radiation is considered the only potentially curative local therapy for such cases. However, recurrence rates range from 10-60% so hyperthermia has been clinically tested in hopes of boosting the effect of CFRT. The article’s authors examined five such studies in particular that involved hyperthermia combined with CFRT with the intent of effecting a radical treatment. Earlier studies of hyperthermia combined with traditional external beam radiation were few, but more recent efforts involved CFRT at a radiation dose of > 70 Gy because recurrence is thought to be lower with this modality. In addition, androgen deprivation therapy to reduce testosterone was also administered to the patients, again in an effort to increase the effect of the radiation. In reviewing the five studies, the authors compare overall survival rates, biochemical disease recurrence and quality of life reported by patients.

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It appears from all studies that the hyperthermia itself does not add side effects beyond what the radiation itself creates, or the radiation plus ADT. On the other hand, there did not appear to be a clear benefit in terms of increased survival or decreased rates of recurrence. One rather alarming effect occurred among patients whose prostate cancer was not yet hormone resistant. The addition of hyperthermia in these patients actually seemed to reduce the amount of time before the cancer became refractory. Therefore, the authors suggest that the combination of hyperthermia and CFRT only be used for locally advanced cancer that has already become hormone-resistant prior to the hyperthermia treatment. They caution, though, that skilled doctors and nurses are required to administer hyperthermia: Structurally, the prostate is a nonuniform structure; heat deposition is not uniform and the PSA level is temperature sensitive… In summary, it appears that the benefits of hyperthermia as an additional therapy to enhance CFRT are inconclusive, and further study needs to occur to explore how well it might enhance the effectiveness of chemotherapy in metastatic prostate cancer.

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Baronzio G, Gramaglia A, Fiorentini G. Current role and future perspectives of hyperthermia for prostate cancer treatment. Hyperthermia admin 2019-04-09T16:54:15+00:00 One of our best treatments to fight and possible eliminate cancer is: Hyperthermia. The definition: the elevation of the body temperature, for us in the medical area. But we all know it, in the most common type of hyperthermia there is: FEVER. Fever is one of the body’s defense mechanisms, that is activated by external factors such as: infections, intoxications and internal factors such as: chronic diseases, like cancer.
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