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J Natl Cancer Inst. PubMed Google Scholar 24. Mason KA, Kishi K, Hunter N, Buchmiller L, Akimoto T, Komacki R, Milas L. Effect of docetaxel on the therapeutic ratio of fractionated radiotherapy in vivo. Clin Cancer Res. PubMed Google Scholar 25. Formenti SC, Symmans WF, Volm M, Skinner K, Cohen D, Spicer D, Danenberg PV.

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Concurrent paclitaxel and radiation therapy for breast cancer. Semin Radiat Oncol. PubMed Google Scholar 26. Kosma K, Koukourakis M, Skarlatos J, Zambatis C, Ardavanis A, Beroukas K, Yannakakis D. Hypofractionated radiotherapy with 5-fluorouracil radiosensitization for locally far advanced breast cancer.

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Am J Clin Oncol. PubMed Google Scholar 27. Formenti SC, Volm M, Skinner KA, Spicer D, Cohen D, Perez E, Bettini AC, Groshen S, Gee C, Florentine B, et al. Preoperative twice-weekly paclitaxel with concurrent radiation therapy followed by surgery and postoperative doxorubicin-based chemotherapy in locally advanced breast cancer: A phase I/II trial. J Clin Oncol.
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However, not all of these studies have shown increased survival in patients receiving the combined treatments.

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What are the different methods of hyperthermia? Several methods of hyperthermia are currently under study, including local, regional, and whole-body hyperthermia. In local hyperthermia, heat is applied to a small area, such as a tumor, using various techniques that deliver energy to heat the tumor. Different types of energy may be used to apply heat, including microwave, radiofrequency, and ultrasound. Depending on the tumor location, there are several approaches to local hyperthermia: External approaches are used to treat tumors that are in or just below the skin.

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I recommend checking that out if you want a minimally invasive treatment. HIFU is definitely not minimally invasive, since it destroys the prostate. Ezra18 Regular Member Joined: Oct 2011 Posts: 35 Posted 11/29/2011 11:17 PM Actually i had Hyperthermia plus 6 months CAB in Germany Oct 7 with Dr. Douwes and am looking for other who may have gone besedes the 5 Canadiansdd I know who went these past 2 months The cost is about $10,000 i n Germany In California they add radiation instead of CAB The best part, besides few side effects. I understand, is this procedure does not preclude RP or Radiation if the cancer returns IRD1956 Regular Member Joined: Mar 2013 Posts: 24 Posted 3/24/2013 12:04 AM Hi, I was diagnosed with Pca, Gleason 3-4=7 at age 55. PSA max 14. I had trans-urethral hyperthermia at Klinic St Georg in January 2011 after which I had 2 clear 3D Doppler Ultrasounds here in Australia.

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A specialist is creating the hyperthermia, so it is natural for the body to defend itself and fight to maintain the normal temperature.

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This is where the hyperthermia system of choice and its employment skills are of great importance. The system consists of a pump with a heater where the steady flow and temperature is determined by the physician but regulated by a computer, which leaves no room for human error. The first step is to place a central two-sided catheter, which will allow us to obtain a high output and return flow, this catheter is placed in the left sub-clavian area and the catheter is connected to the hyperthermia system, once the system is connected and programmed, blood is pumped through the hyperthermia system which exits through the catheter to reach the heater and will gradually raise the temperature of the blood and later the whole body. Yes, hyperthermia has proven to enhance the effect of chemotherapy or radiation, when combine with either of them. The positive results of randomize trials have establish hyperthermia in combination with chemotherapy as a novel clinical modality for the treatment of cancer. Hyperthermia targets the action of chemotherapy within the tumor heated region without affecting systemic toxicity.

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Studies show there are great benefits when patients have a 2 to 4 hours session of constant and sustained hyperthermia. Rapid induction of hyper thermic state. Our perfusion system takes approximately 20 to 25 minutes maximum to reach the desired temperature. The patient is alert, avoiding the need for sedation due to heat intolerance and the prolonged time that it takes to carry out the therapy. The patient does not report any discomfort, allowing us to maintain therapeutic sessions for a much larger period, and hence, achieving in a single session, what would take us up to 8 sessions to achieve with other methods. It helps and improves muscle and bone pain; thanks to the immunomodulatory effect it brings.

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Physicians can control the patient’s core body temperature, something that cannot happen with other techniques. Contrary to the belief that a full-scale hospital with such prestigious reputation will be very expensive, patients that have decided to get our treatments constantly tell us that the one of the main reasons they decided for us over others, is our straight-forward affordable price without any sneaky pricing gimmicks or up sales. Once you receive our treatment quote, that is final, and we won’t try to up sale or pressure you into anything you’re not comfortable with. The treatment price varies for each patient, mainly because each patient’s needs, and medical circumstances are very different and require different attention. Once our doctors receive your medical information, they will assess your medical needs and if an outpatient plan is an option, this will be presented to you, saving you the costs of an in-hospital stay while still getting the same treatment you would as an in-patient. To obtain a better understanding of the treatment price for a specific situation, please fill out the inquiry form to provide our case manager and medical doctors the necessary information to evaluate your case and provide a precise estimate with no commitment.
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PMC free article PubMed Google Scholar 12.

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Hortobagyi GN, Singletary SE, Buchholz TA. Locally advanced breast cancer. In: Singletary SE, Robb GL, Hortobagyi GN, editors. Advanced therapy of breast disease. Ontario: BC Decker; 2004. Google Scholar 13. Skinner KA, Dunnington G, Silberman H, Florentine B, Spicer D, Formenti SC.

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Preoperative 5-fluorouracil and radiation for locally advanced breast cancer. Am J Surg. PubMed Google Scholar 14. Kao J, Conzen SD, Jaskowiak NT, Song DH, Recant W, Singh R, Masters GA, Fleming GF, Heimann R. Concomitant radiation therapy and paclitaxel for unresectable locally advanced breast cancer: Results from two consecutive phase I/II trials. Int J Radiat Oncol Biol Phys.

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PubMed Google Scholar 15. Antman K, Ayash L, Elias A, Wheeler C, Hunt M, Eder JP, Teicher BA, Critchlow J, Bibbo J, Schnipper LE. A phase II study of high-dose cyclophosphamide, thiotepa, and carboplatin with autologous marrow support in women with measurable advanced breast cancer responding to standard-dose therapy. J Clin Oncol. PubMed Google Scholar 16. Shen ZZ, Zhang YW, Pan TX, Xia CJ. Multidisciplinary approach to the treatment of unresectable breast cancer.
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But we all know it, in the most common type of hyperthermia there is: FEVER.

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Fever is one of the body’s defense mechanisms, that is activated by external factors such as: infections, intoxications and internal factors such as: chronic diseases, like cancer. Fever has different symptoms, among them is hyperthermia. When these symptoms start to appear, our body knows that something is not right and there are two different scenarios: When our immune system is strong and healthy, it becomes hypersensitive and finds any cancer cells to be out of the ordinary and therefore kills them daily. There are times when our immune system doesn’t detect the cancer cells and the cancer spreads throughout the body. The hyperthermia that we offer at the Functional Oncology Center is highly effective and we are the ONLY provider that does a systemic perfusion hyperthermia in Mexico   The hyperthermia that we offer at the Functional Oncology Center is highly effective and we are the ONLY provider that does a systemic perfusion hyperthermia in Mexico   For doctors, cancer is a possible combination of different diseases that are present in the body and together they form a tumor. The most important battle against cancer is fought at our cellular level, where the malignant cells are reproducing.

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However, all cells have a weakness and in this case, cancer cells can´t take temperatures between 39 to 42 degrees Celsius, it generates stress in them. At our Functional Oncology Center, we can generate hyperthermia in the patient’s body in a controlled environment, monitoring their vital signals at every moment. At this moment, the cell membrane of the malignant cells is unstable and permeable, making easy to penetrate the cell with a killing agent, to generate a better effect and results. In addition, hyperthermia induces the malignant cell to release surface antigens important for immune recognition and activation; this is a cardinal point for our therapies. Types of hyperthermia:  Regional: refers to the increase of temperature to hyper thermic levels of a single zone or area.

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Systemic: This is whole body hyperthermia, refers to the increase in temperature to hyper thermic levels over the entire body. Our medical staff will perform a specific evaluation, to determine if this treatment is the best option for our patient, if they are in optimal condition and is it safe to perform. Our doctors have combined the principles used in cardiology and nephrology to build an advanced hyperthermia equipment, used specifically for our hyperthermia cancer treatment. A specialist is creating the hyperthermia, so it is natural for the body to defend itself and fight to maintain the normal temperature. This is where the hyperthermia system of choice and its employment skills are of great importance. The system consists of a pump with a heater where the steady flow and temperature is determined by the physician but regulated by a computer, which leaves no room for human error. The first step is to place a central two-sided catheter, which will allow us to obtain a high output and return flow, this catheter is placed in the left sub-clavian area and the catheter is connected to the hyperthermia system, once the system is connected and programmed, blood is pumped through the hyperthermia system which exits through the catheter to reach the heater and will gradually raise the temperature of the blood and later the whole body.
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