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Ancient Greek physicians recognized the therapeutic value of fever.

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In the nineteenth century several German physicians observed regression or cure of sarcomas in patients who suffered prolonged high fevers due to infectious diseases. Nineteenth century New York physician, William Coley, achieved cancer cures by administration of bacterial endotoxins, now known as Coley’s Mixed Bacterial Vaccine, and attempted to create standardized preparations of these pyrogens. Since 1951, Josef M. Issels, MD, the founder of our Integrative Oncology programs, consistently administered fever therapy to thousands of his cancer patients with remarkable results. He trained his followers in this treatment and our present team of doctors have extensive experience in administering fever therapy for qualified patients. It is always integrated into our immunobiological core treatment.

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Additional Information on Medical Hyperthermia Treatment Apart from the induction of biological fever by pathogens or toxins, all methods of hyperthermia involve transfer of heat into the body from an external energy source. Different types of energy may be used to apply heat including microwave, radio frequency and ultrasound. It was in the first decades of the twentieth century that the biological effects of elevated body temperature were better understood and numerous devices were developed to apply therapeutic heat to the whole body. After a shift in focus to local and regional hyperthermia, there is now growing interest in systemic hyperthermia in view of its advantages. The goal of systemic hyperthermia is to reproduce the beneficial effects of fever.

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